Parkinson’s Drugs and Restless Leg Syndrome Drugs Triggering Gambling Addiction.
Some years back i got a call from a man seeking help for gambling addiction.
He said i am on a pill for Parkinson disease and became a compulsive gambler.
I thought what bull this is. Then i started to get lots of calls ,e mail,and have seen in person people with the same story.
Right now i am working to help a man with a gambling addiction who never gambled before taking the pill for his Parkinson problem and in the last 2 years has lost over $200,000.
Patients with Parkinson’s disease are about five times more likely to become problem or pathological gamblers than others, concludes a new Canadian study that offers some of the most dramatic evidence to date of the unusual link.
In a paper just published in the Journal of Gambling Studies, they urge that all Parkinson’s patients now be screened for possible gambling problems, and monitored through the course of their treatment.
Scientists theorize that the problem is caused by drugs that counter the shortage of dopamine in Parkinson’s patients’ brains, the main cause of their symptoms. As well as managing movement and balance, the chemical influences the pleasure and reward centres of the brain, perhaps encouraging such compulsive behaviour as gambling.
A popular medication used to control tremors associated with Parkinson’s Disease and Restless Leg Syndrome has caused people to get addicted to gambling addiction.
Dopamine agonist works by mimicking the effects of this neurotransmitter. Parkinson’s Disease occurs because of a lack of dopamine in certain areas of the brain. Dopamine helps people control their movements and increases feelings of happiness and satisfaction.
Dopamine agonists are powerful drugs, and can drastically alter brain chemistry. For example, dopamine is known to produce a “rush” in the brain of people who are anticipating a reward or excitement. Many experts believe that such a biochemical reaction is behind the reports of compulsive behavior linked to these drugs.
THIS MIGHT BE GOOD FOR RESEARCHERS TO LOOK AT TO GET SOME UNDERSTADING OF THE GAMBLING ADDICTION.
ARNIE WEXLER CCGC
WWW.ASWEXLER.CO
ASWEXLER@AOL.COM
HELPLINE FOR GAMBERS 888 LAST BET
HOME 561 2490922 CELL 954 501 5270
What is Compulsive Gambling?
BY ARNIE WEXLER CCGC
Compulsive gambling is a progressive disease, much like an addiction to alcohol or drugs. In many cases, the gambling addiction is hidden until the gambler becomes unable to function without gambling, and he or she begins to exclude all other activities from their lives. Inability to stop gambling often results in financial devastation, broken homes, employment problems, criminal acts and suicide attempts.
The gambler is eventually able to remove themselves from reality to the point of being totally obsessed with gambling. Eventually, they will do anything to get the money with which to stay in “action”. They will spend all their time and energy developing schemes in order to get the money to continue gambling. Lying becomes a way of life for the gambler.
They will try to convince others and themselves that their lies are actually truths and they will believe there own lies.
After they hit a real bottom they will have to do something if they want to try to recover. Most gamblers at that point will want to stop but can’t (they wont be able to).
Most even at that point will keep gambling some will end up in jail some will attempt suicide some will die from their addiction as they will not take care of their health or the stress will kill them.
And a small group of addicted gamblers will seek and find real help but the real trick is to get in to real recovery. Not just abstinence. By the time the gambler comes for help they have broken brains (Meaning their brains don’t work like they used to when they were not in there addiction).
To get real recovery the gambler needs to work on them self’s one day at a time and get someone to do there thinking for them who has been in recovery some time and has there brains are working right (a sponsor) After some time in recovery there brains will start to work again. They will become productive on there job and become a good father and husband. Recover is a process and does not happen with out a lot of work on your self . and making a moral and financial inventory. But people can recover and do.—————
Nine gambling myths
From Arnie and Sheila Wexler, who present workshops and seminars on compulsive
gambling addiction and run a national hotline for problem gamblers: 888-LAST BET:
1. The big win is just around the corner with the next bet I make.
2. I can get even again, then I will stop gambling.
3. I am not like drug addicts or alcoholics.
4. I can stop anytime I want. I just don’t want to stop.
5. I am too young to be a gambling addict.
6. If I had more money I know I could win.
7. I am smarter than the rest of the gamblers.
8. The losses are not my fault right now because I’m having bad luck.
9. I know I can beat this game.
THIS IS FROM A LADIE WHO NOW IS IN RECOVERY
I have to tell you , in 2005, it was one night I had a very strong impulse. I didn?t know what was going on with me, I knew nothing about impulses. All I knew at that time it was ? I don?t want to gamble anymore. It is killing me. So that night I had chain myself to calorifere (Heater) with little handcuffs I have spited out the window little keys and for the whole night I was sweating (perspired), crying and I was by myself. I was in pain. I think it was the worst night in my life. As I see it now, I had one impulse after another that night. I couldn?t go to the bathroom so you can imagine what?In the morning I called on mobile my neighbour ? she went down (as I live on the second floor) and she found the keys and released me.———–
============
MY FRIEND WHO WENT BACK TO GAMBLING AFTER YEARS IN RECOVERY
I lost all of my savings, 3 houses I owned, and my Cadillac. In spite of this,I’m a little surprised that you continue to try to get me to stop, because I really feel that if all of the above hasn’t helped me to reach any bottom at all, that I never will.
Each time I start a little winning streak, I believe that this is the beginning of a continuing future of a successful gambling life Now I truly believe that I can make that happen.
==================
LONDON
Compulsive gambler is ‘cured’ by brain surgery
A compulsive gambler who lost thousands on fruit machines has undergone radical brain surgery to cure his addiction.
Raymond Mandale, 58, took the drastic decision after losing more than £10,000 at his local bingo hall in a single year.
During a six-hour operation which cost £30,000 surgeons fitted a “neuro stimulator” to Mr Mandale’s brain.
The battery-operated device is then used to send electrical pulses to “reset” the area that stimulates the desire to gamble.
The surgery, which was paid for by the NHS, is now Mr Mandale’s last hope of beating his addiction.
Normally used to treat patients with Parkinson’s Disease, new research has shown it can also benefit those with addictive personalities.
Mr Mandale, of Workington, Cumbria, claims it was side effects from drugs he was given to treat the effects of Parkinson’s that caused him to start gambling in the first place.
=======================================
Brain scans show that excessive gambling and drug addiction activate the same parts of the brain.
Gambling addiction may have something in common with certain brain impairments.
Both conditions can hinder decision-making and the ability to determine the consequences of actions, according to Franco Manes, MD, and colleagues. They say it’s possible that gambling addiction is associated with impairments in the brain’s prefrontal cortex, affecting the ability of gamblers to consider future consequences before taking action.
Newser) – After four years of work involving 80 experts, the American Society of Addiction Medicine is redefining addiction—to alcohol, drugs, sex, gambling, and more—as a brain disorder, updating its former classification as a behavioral problem, reports Live Science. Addiction is also now considered a primary and chronic disorder, meaning it is not the result of stress, abuse, or other causes, and it needs to be treated over a patient’s lifetime, just as one would deal with a chronic disease like diabetes.
ASAM officials were swayed in part due to advancements in neuroscience over the last 20 years, which have shed light on the fact that the brain circuitry that regulates impulse control and judgment is altered in addicts’ brains. “We have to stop moralizing, blaming, controlling or smirking at the person with the disease of addiction,” said an addiction researcher. “The disease is about brains, not drugs.”
=========================
Randy Shore, Vancouver Sun CANANDA
Published: Friday, February 29, 2008
The thrill of risk and the intermittent rewards experienced by gamblers appear to “hijack” the brain’s natural reward systems, according to University of B.C. researcher Catharine Winstanley.
“Gambling has a tendency to become very addictive in the same way that crack cocaine does,” said Winstanley.
Gambling can affect the areas of the brain associated with planning and forming strategies.
“In people that develop problems with gambling it seems that parts of that area don’t work as well as they used to,” she said. In adults, such experiences can change the way neurons in the brain fire and in drug addicts, research has found that those changes can be permanent.
=======================
PARKINSONS AND GAMBLING
From The Times
February 20, 2009
Gambling blows your mind
The inherently unpredictable nature of gambling makes it hard for our brains to recover from the dopamine high it generates
Jonah Lehrer
I am a sucker for financial bubbles. The first stock I bought was Cisco Systems, in early 2000. It was the height of the dot-com bubble and Cisco was about to become the most valuable company in the world. Naturally my investment crashed too.
I’d like to say that I learnt from my dot-com disaster, but I didn’t. In late 2006 I began investing in blue-chip financial stocks, such as Citibank and Bank of America. At the time these companies were reporting record profits as they expanded into the sub-prime mortgage business. We all know how that turned out.
If there’s any consolation from my losses it’s that I wasn’t the only one. The current economic crisis is a by-product of collective failure, an example of terrible decision-making on a huge scale. Banks gave out loans to people who shouldn’t have taken them, consumers got used to spending money they didn’t have, regulators failed to regulate, and investors, appeased by ephemeral profits, failed to ask hard questions.
In retrospect we can see the profound foolishness of this behaviour. Yet it’s worth remembering that this is not the first time that the markets have gone haywire. The history of finance is largely a history of financial bubbles, from the tulip mania of 17th-century Holland to the South Sea Bubble of 18th-century England. Do we never learn? And, if not, why not?
The answer to these questions returns us to the human brain, in particular a single neurotransmitter in the brain – dopamine – that seems to play a crucial role in shaping the behaviour of investors. While dopamine is an essential ingredient of cognition – it helps us to process and predict rewards, from a bite of chocolate cake to stock market profits – this neurotransmitter system can also be led astray, with often devastating consequences.
Ann Klinestiver was a high school English teacher in a small town in West Virginia when she was found to have Parkinson’s disease. She was only 52, but the symptoms were unmistakable. “I lost control of my body,” she says. “I’d look at my arm and I’d tell it what to do but it just wouldn’t listen.”
Parkinson’s is caused by the death of dopamine neurons in a part of the brain that controls bodily movements. Klinestiver’s neurologist put her on a dopamine agonist, a class of drug that imitates the activity of dopamine in the brain. “At first, the drug was like a miracle,” she says. “All my movement problems just disappeared.” Over time, however, higher doses of the drug were required to quieten her tremors.
That’s when she discovered slot machines. It was an unlikely discovery. “I’d never been interested in gambling,” Klinestiver says. But after she started taking the medication she found the machines at her local dog-racing track completely irresistible. She would start gambling as soon as the track opened, at 7 in the morning, and would keep playing the machines until 3.30 the next morning, when the security guards kicked her out. “Then I would go back home and gamble on the internet until I could get back to the real machines,” she says. “I was able to keep that up for two or three days at a time.”
After a year of addictive gambling she had lost more than $250,000 (£176,000). She had exhausted her retirement savings and emptied her pension. “I knew I was destroying my life but I just couldn’t stop,” she says. In 2006, Klinestiver was finally taken off her dopamine agonist. Her movement problems came back but the gambling compulsion disappeared. And she isn’t the only one. Medical studies suggest that as many as 13 per cent of patients taking dopamine agonists develop severe gambling compulsions. People with no history of gambling suddenly become addicts. While most of these people will obsess over slot machines, others will become hooked on internet poker or blackjack. They will squander everything they have on bets that are stacked against them.
At first glance, slot-machine addiction seems to have nothing to do with financial bubbles. I was buying Citibank stock, not sinking quarters into a one-armed bandit. And yet, Klinestiver’s tragedy also reveals a serious flaw in the dopamine system. It’s a flaw that is constantly being exploited, from the casino floor to the stock market, and it’s ultimately rooted in the way that our brain cells make sense of the world.
Wolfram Schultz, a neuroscientist at the University of Cambridge, has exposed how the dopamine system works at a molecular level. His experiments follow a simple protocol: he plays a loud tone, waits for a second or two and then squirts a few drops of apple juice into the mouth of a monkey. While the experiment is unfolding, Schultz monitors the electrical activity inside individual cells. At first the dopamine neurons fire only when the juice is delivered; the cells are responding to the actual reward. However, once the animal learns that the tone precedes the arrival of juice, the same neurons begin firing at the sound of the tone
instead of the reward. Schultz calls these cells “prediction neurons” since they are more concerned with predicting rewards than receiving them. Once this pattern is memorised, the monkey’s dopamine neurons become exquisitely sensitive to variations on it. If the cellular predictions are correct, and the reward arrives right on time, then the primates experience a brief surge of dopamine, the pleasure of being right
Games of chance prey on this neural system. Think, for instance, about how a slot machine works. You put in a coin and pull the lever. Eventually, the machine settles on its verdict. Since slot machines are programmed to return only about 90 per cent of wagered money, the chances are you lost money. Now think about the slot machine from the perspective of your dopamine neurons. The purpose of these cells is to predict future events. While you are playing the slots, inserting quarter after quarter, your neurons are struggling to decipher the patterns inside the machine.
But here’s the catch: while dopamine neurons get excited by predictable rewards – they increase their firing when the juice arrives after the loud tone – they get even more excited by surprising ones. The purpose of this dopamine surge is to make the brain pay attention to new, and potentially important, stimuli.
Most of the time the brain will eventually get over its confused delight. We will figure out which events predict the reward, and our dopamine neurons will stop releasing so much neurotransmitter. The danger of slot machines, however, is that they are inherently unpredictable. Because they use random number generators, there are no patterns to uncover.
At this point, our dopamine neurons should simply surrender: the slot machine is a waste of mental energy. But this isn’t what happens. Instead of getting bored by the haphazard payouts, our dopamine neurons become obsessed. When we pull the lever and get a reward, we experience a rush of pleasure precisely because the reward is so unexpected – the clanging coins are like a surprising squirt of juice. The end result is that we are transfixed by the slot machine, riveted by the fickle nature of its payouts.
For patients with Parkinson’s who are on dopamine agonists, the surprising rewards of the casino trigger a huge release of chemical bliss. Their surviving dopamine neurons are so full of dopamine that the neurotransmitter spills over and pools in the empty spaces between cells. Such patients are so blinded by the pleasures of winning that they slowly lose everything. That’s what happened to Klinestiver.
The lesson of slot machines is that our brain is not good at dealing with randomness, which leads us to search for patterns where there is only accidental chance. Look, for instance, at the the stock market. Economists refer to the stock market as a “random walk” since the past movement of any particular stock cannot be used to predict its future movement. In this sense, Wall Street is like a slot machine.
The danger of the financial markets, however, is that their erratic fluctuations often look predictable, at least in the short term. Our dopamine neurons are determined to solve the flux – but most of the time there is nothing to solve. Read Montague, a neuroscientist at Baylor College of Medicine who studies the dopamine pathway, recently demonstrated how an urestrained dopamine system can lead, over time, to dangerous stock-market bubbles. The experiment went like this: subjects were given $100 and some basic information about the “current” state of the stock market. Then they chose how much of their money to invest. After making up their minds the players nervously watched as their stock investments either rose or fell in value. The game continued for 20 rounds, and the subjects got to keep their earnings. One interesting twist was that, instead of using random simulations of the stock market, Montague relied on distillations of data from famous historical markets, such as the Dow of 1929, Nikkei of 1986 and the Nasdaq of 1998. This let the scientists monitor the neural responses of investors during real-life bubbles and crashes.
How did the brain deal with the fluctuations of Wall Street? The scientists immediately discovered a strong neural signal, emanating from dopamine-rich areas of the brain, that seemed to be driving many of the investment decisions. Take, for example, this situation. A player has decided to wager 10 per cent of his total portfolio in the market, which is a rather small bet. Then, he watches as the market rises dramatically in value. Here’s where the experiment gets interesting: because our dopamine neurons are obsessed with predicting rewards they start making predictions about what will happen next. Since the market has just gone up, these cells assume that it will continue to go up, which led the investors to perpetually increase their investments. The end result was an escalating feedback loop of dopamine as the brain made reward predictions – the market will continue to rise – and then watched as those predictions came true.
Montague argues that these dopamine neurons are also a main cause of financial bubbles. When the market keeps going up, people are naturally led to make larger investments in the boom. (This is precisely what happened to me when I bought shares in Cisco and Citibank.) Their greedy brains are convinced that they have solved the stock market, and they forget about the possibility of a loss. But then, just when investors are most convinced that the bubble isn’t a bubble, the bubble bursts. At this point investors race to dump any assets that are declining in value as their neurons realise they have made some expensive prediction errors. That’s when you get a financial panic.
The lesson, and it’s a lesson that I’ve learnt the hard way, is that it’s silly to try to beat the market with our brains. Dopamine neurons weren’t designed to deal with the oscillations of Wall Street. When we spend lots of money on investment management fees, or sink our savings into some hot hedge fund, or buy shares in companies because everybody else is buying them, we are slavishly following our primitive reward circuits, just like a gambler losing a fortune in a casino. That’s why a randomly selected stock portfolio will, over the long run, beat the expensive experts with their fancy computer models. Or why the vast majority of mutual funds in any given year will underperform the S&P 500.
Because the market is a random walk with an upward slope, investors who do nothing to their stock portfolio – they don’t buy or sell a single stock – outperform the average “active” investor by nearly 10 per cent. Wall Street has always searched for the secret algorithm of financial success, but the secret is that there is no secret. The world is more random than we can imagine. That’s what our brain is unable to understand.
Jonah Lehrer is a science writer and the author of Proust Was a Neuroscientist. His new book, The Decisive Moment: How the Brain Makes Up Its Mind, is published by Canongate.
——————————————
Arnie Wexler ccgc
HELP LINE 888 LAST BET
561 249 0922 CELL 954 5015270
ASWEXLER@AOL.COM
WWW.ASWEXLER.COM